GL Stories

Hear from others with GL

Learn from the experiences of real people with GL – and get insights from parents of children with GL.


  • Lives in Texas
  • Has congenital GL
  • Taking Myalept since 2000

“After I started taking Myalept, my triglyceride levels started going down.”

Camerin and Lorelei

  • Live in California
  • Camerin’s daughter, Lorelei, lives with acquired GL
  • Taking Myalept since 2012

Once Lorelei started Myalept to replace her missing leptin, her triglycerides and blood glucose numbers got better.

Jason and Troy

  • Live in Michigan
  • Jason’s son, Troy, lives with acquired GL
  • Taking Myalept since 2010

When Troy started losing fat all over his body, we knew something was seriously wrong.


  • Lives in New Jersey
  • Has congenital GL
  • Taking Myalept since 2009

Looking back now, I had a lot of the signs of GL.

Jilandre and Raeya

  • Live in Maryland
  • Jilandre’s daughter, Raeya, lives with congenital GL
  • Taking Myalept since 2010

Leptin is a hormone that Raeya’s body doesn’t make enough of, and Myalept is a leptin replacement therapy, so it made sense for Raeya to start Myalept right away.

Important Safety Information

What is Myalept?

Myalept® (metreleptin) is a leptin replacement therapy used with a doctor-recommended diet to treat problems caused by not having enough leptin (leptin deficiency) in people with generalized lipodystrophy.

Important Safety Information

Myalept is only available through a restricted program called the Myalept Risk Evaluation and Mitigation Strategy (REMS) Program. Your doctor must be enrolled and certified in the program in order to prescribe Myalept.

Myalept may cause serious side effects, including:

You should not take Myalept if you:

Before using Myalept, tell your doctor if you have any medical conditions including if you:

Other possible side effects

The most common side effects of Myalept include headache, low blood sugar, decreased weight, and/or abdominal pain.

You may get low blood sugar (hypoglycemia) if you take Myalept with other medicines used to lower blood sugar, such as insulin or sulfonylurea. Your doses of these medications may need to be lowered while you use Myalept. Tell your doctor right away if you experience shakiness, sweating, headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, or a jittery feeling because these may be signs of low blood sugar (hypoglycemia).

For newborns and infants, mix Myalept with sterile water for injection (preservative-free) (WFI). Serious side effects including death have happened in newborns or infants who have received the preservative benzyl alcohol. Bacteriostatic water for injection contains benzyl alcohol and it should not be used to mix Myalept for newborns and infants.

Myalept may worsen symptoms caused by certain problems in your immune system (autoimmune disorder). Ask your doctor about what symptoms you should watch for that may require further testing.

Talk to your doctor about any side effect that bothers you or that does not go away. These are not all the possible side effects of Myalept. For more information, speak to your doctor or pharmacist. Tell your doctor about all the medications you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Take Myalept exactly as your doctor instructs you.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit or call 1-800-FDA-1088.

This is the most important information about Myalept. For more detailed information, please see the patient Medication Guide and full Prescribing Information including Boxed Warning.