Because of the lack of fat and the lack of leptin in my system, I was constantly eating, and my blood sugar and triglycerides were very high.
People with GL do not have enough leptin
Generalized lipodystrophy (GL) is a rare disease that results in having little to no fat tissue all over the body. Not only does the disease affect your appearance, the lack of body fat results in a loss of leptin, an important hormone that helps the body function properly.
Leptin is vital because it helps control some key metabolic processes in the body. Not having enough leptin can lead to health problems such as high triglycerides (fat in the blood) and high blood sugar. This is where Myalept®, the only FDA-approved leptin replacement therapy, may be able to help.
Three things you need to know about leptin
Controlling how fat is broken down or stored. When fat is not used and stored properly, it can collect in places it should not, for example, in organs, such as the liver and muscles, and also as triglycerides in the blood.
Helping the body respond to insulin. Insulin is a hormone produced by the pancreas that helps manage levels of sugar in the blood. Without leptin, the body can develop insulin resistance, which may lead to diabetes in people with GL.
Telling the body when you have eaten enough food. Without this signal, people with GL may be constantly hungry, even after eating a full meal.
When leptin levels are too low, health can be affected
When important metabolic functions in the body are not controlled, it can lead to serious health problems, such as high triglycerides and high blood sugar.
To track these problems, people with GL should be aware of 3 important measures:
- Triglyceride level. This is the amount of fat in the blood.
- Blood sugar level, also referred to as blood glucose level. This is the amount of sugar in the blood.
- A1C level. This is a measure of the average blood sugar level over the course of 2 to 3 months. When blood sugar levels are too high, the risk of developing diabetes can increase in people with GL.
Not having enough leptin can cause these levels to be higher than normal in people with GL. Simple blood tests ordered by your doctor can show the level of triglycerides and sugars in the blood.
Because people with GL are often hungry, the extra fats and sugars taken in from food can make these high levels much worse, resulting in a continuous cycle.