Because of the lack of fat and leptin in my system, my blood sugar and triglycerides were very high.
People with GL do not have enough leptin
Generalized lipodystrophy (GL) is a rare disease that results in having little to no fat tissue all over the body. Not only does the disease affect your appearance, the lack of body fat results in a loss of leptin, an important hormone that helps the body function properly.
Leptin is important because it helps control some key metabolic processes in the body. Not having enough leptin can lead to high triglycerides (fat in the blood) and high blood sugar. This is where Myalept®, the only FDA-approved leptin replacement therapy, may be able to help. Talk to your doctor to see if Myalept is right for you.
Leptin helps control certain important metabolic processes in the body:
Controlling how fat is broken down or stored. When fat is not used and stored properly in GL, it can collect as triglycerides in the blood.
Helping the body respond to insulin. Insulin is a hormone produced by the pancreas that helps manage levels of sugar in the blood. Without leptin, the body can develop insulin resistance, which may lead to diabetes in people with GL.
How GL and low leptin levels can affect you
People with GL have leptin deficiency and should track 3 important measures:
To track these problems, people with GL should be aware of 3 important measures:
- Triglyceride level. This is the amount of fat in the blood.
- Blood sugar level, also referred to as blood glucose level. This is the amount of sugar in the blood.
- A1C level. This is a measure of the average blood sugar level over the course of 2 to 3 months. When blood sugar levels are too high, the risk of developing diabetes can increase in people with GL.
Not having enough leptin can cause these levels to be higher than normal in people with GL. Simple blood tests ordered by your doctor can show the level of triglycerides and sugars in the blood.
Because people with GL are often hungry, the extra fats and sugars taken in from food can make these high levels worse, resulting in a continuous cycle.